Hydrochloric Acid → 6-Benzoyl-5-nitropyridin-2(1H)-one

Participants

Reaction Conditions

Reaction Steps

50 grams of 2-(α-cyanobenzyl)-3-nitro-6-chloropyridine were dissolved in 200 ml. of acetone, 70 ml. of 30% aqueous hydrogen peroxide added and then with stirring there was gradually dropped a solution of 39 grams of KOH in 50 ml. of water with stirring. The solution heated by itself to 35° C. After 40 minutes there was no blue coloration upon dropwise adding further potassium hydroxide solution. The yellow-red solution was diluted with water and acidified with hydrochloric acid. The 2-benzoyl-3-nitro-6-hydroxypyridine crystallized out and was filtered off with suction after an hour and dried.

Provenance & Evidence