反应详情

温度

100 °C

A mixture of 294 g. of 6-fluoroquinoline, 74.6 g. of quinaldine, 1.7 l. of chlorobenzene and 254 g. of iodine is stirred for 2 hours at 20°-25° C., then stirred and heated at 100° C. for 4 days. About 1 l. of solvent is removed by evaporation at reduced pressure and the residue is cooled to 0°-5° C. The precipitate is collected, washed with cold chlorobenzene, dried and pulverized. The finely divided solid is suspended with stirring and cooling in 500 ml. of methanol and 55 ml. of hydrazine is added to destroy excess iodine. The resulting solid 3-fluoroimidazo[1,2-a:3,4-a']diquinolin-15-ium iodide is collected by filtration, washed with cold methanol and dried; m.p. 310°-316° C.

1. additionA mixture of 294 g
2. customof solvent is removed by evaporation at reduced pressure
3. temperaturethe residue is cooled to 0°-5° C
4. customThe precipitate is collected
5. washwashed with cold chlorobenzene
6. customdried
7. stirringwith stirring
8. temperaturecooling in 500 ml
9. additionof hydrazine is added
10. customto destroy excess iodine
11. filtrationThe resulting solid 3-fluoroimidazo[1,2-a:3,4-a']diquinolin-15-ium iodide is collected by filtration
12. washwashed with cold methanol
13. customdried