Iodine → HCID 20335504, compound

Participants

Reaction Steps

A mixture of 614 g. of quinoline, 192 g. of 6-fluoroquinaldine [J. Org. Chem. 42, 911 (1977)], 2.0 l. of chlorobenzene and 602 g. of iodine is stirred at 25°-30° C. for 2 hours, then heated at 95°-100° C. for 90 hours. The mixture is cooled and the precipitate is collected, washed with cold chlorobenzene and suspended in 1.5 l. of methanol. The methanol suspension is stirred with 150 ml. of hydrazine hydrate and the resulting solid 10-fluoroimidazo[1,2-a:3,4-a']diquinolin-15-ium iodide is collected by filtration; m.p. 330°-334° C., after crystallization from methanol.

Provenance & Evidence