Iodine → HCID 20335477, compound

Participants

Reaction Steps

A mixture of 85.0 g. of 6-cyclohexylquinoline, 16.4 g. of 6-fluoroquinaldine, 150 ml. of toluene and 51.6 g. of iodine is stirred for 30 minutes at 20-25° C., then heated at 95°-100° C. for 6 days. The mixture is cooled, diluted with 300 ml. of chlorobenzene and treated dropwise with hydrazine hydrate until the dark-colored mixture becomes light tan. The precipitate is collected, washed with chlorobenzene and suspended in 400 ml. of cold methanol. The resulting solid 3-cyclohexyl-10-fluoroimidazo[1,2-a:3,4-a']diquinolin-15-ium iodide is collected by filtration and crystallized from dimethylformamide/methanol; m.p. ca 225° C.-235° C.

Provenance & Evidence