反应详情

A mixture of 16.1 g. of 6-fluoroquinaldine, 58.9 g. of 6-fluoroquinoline, 70 ml. of chlorobenzene and 50.8 g. of iodine is stirred at 20°-25° C. for 1 hour, then heated at 95°-100° C. for 4 days. The precipitate is collected and suspended in 300 ml. of methanol. The methanol suspension is treated with 17 ml. of 85% hydrazine hydrate and the resulting solid 3,10-difluoroimidazo[1,2-a:3,4-a']diquinolin-15-ium iodide is collected by filtration; m.p. >360° C., after crystallization from methanol.

1. additionA mixture of 16.1 g
2. temperatureheated at 95°-100° C. for 4 days
3. customThe precipitate is collected
4. additionThe methanol suspension is treated with 17 ml
5. filtrationof 85% hydrazine hydrate and the resulting solid 3,10-difluoroimidazo[1,2-a:3,4-a']diquinolin-15-ium iodide is collected by filtration
6. customm.p. >360° C., after crystallization from methanol