反应详情

To a solution of 12.2 g. ethyl 4-(2-aminoethyl)-phenylacetate hydrochloride in 40 ml dioxane and 40 ml acetone, there is added dropwise, after the addition of 8 ml pyridine, a solution of 12.3 g 2-butoxy-5-chlorobenzoyl chloride in 10 ml acetone. The reaction mixture is then stirred under reflux for 3 hours and thereafter evaporated in a vacuum. The residue is stirred with dilute hydrochloric acid and then with aqueous sodium bicarbonate solution, filtered with suction and washed with water. There are obtained 19 g of crude product which, after recrystallization from ethanol, with the addition of small amounts of water, gives ethyl 4-[2-(2-butoxy-5-chlorobenzamido)-ethyl]-phenylacetate; m.p. 80° C.

1. temperatureunder reflux for 3 hours
2. customevaporated in a vacuum
3. stirringThe residue is stirred with dilute hydrochloric acid
4. filtrationwith aqueous sodium bicarbonate solution, filtered with suction
5. washwashed with water
6. customThere are obtained 19 g of crude product which
7. customafter recrystallization from ethanol
8. additionwith the addition of small amounts of water