5-Bromo-2-methoxybenzoyl chloride → HCID 23453082, compound

HRID 1706475Notes

Reaction equation

HRID 1706475 reaction equation
Br[C:2]1C=CC(OC)=C(C=1)C(Cl)=O.Br[C:14]1[CH:15]=[CH:16][C:17]([O:37][CH3:38])=[C:18]([CH:36]=1)[C:19]([NH:21][CH2:22][CH2:23][C:24]1[CH:29]=[CH:28][C:27]([CH2:30][C:31]([O:33]CC)=[O:32])=[CH:26][CH:25]=1)=[O:20].BrC1C=CC(OC)=C(C=1)C(NCCC1C=CC(CC(O)=O)=CC=1)=O>>[CH3:38][O:37][C:17]1[CH:16]=[CH:15][C:14]([CH3:2])=[CH:36][C:18]=1[C:19]([NH:21][CH2:22][CH2:23][C:24]1[CH:25]=[CH:26][C:27]([CH2:30][C:31]([OH:33])=[O:32])=[CH:28][CH:29]=1)=[O:20]

Participants

4

Reactant 3

HCID 45681135-Bromo-2-methoxybenzoyl chlorideHCID 23453057HCID 23453057, compoundHCID 23453080HCID 23453080, compound

Product 1

HCID 23453082HCID 23453082, compound

Procedure

with 5-bromo-2-methoxybenzoyl chloride, via ethyl 4-[2-(5-bromo-2-methoxybenzamido)-ethyl]-phenylacetate (oil), 4-[2-(5-bromo-2-methoxybenzamido)-ethyl]-phenylacetic acid; m.p. 148°-150° C., after recrystallization from isopropanol.

Workup

  1. customm.p. 148°-150° C., after recrystallization from isopropanol

Sources & evidence

ORD record
ord-24d8ae51faf04116920cead6895bafe8
Source dataset
uspto-grants-1980_06
Patent number
US04207341

Reaction notes

Loading…