5-Chloro-2-methoxynicotinic acid → HCID 23453078, compound

HRID 1706479Notes

Reaction equation

HRID 1706479 reaction equation
ClC1C=NC(OC)=C(C=1)C(O)=O.Cl[C:14]1[CH:15]=[N:16][C:17]([O:37][CH3:38])=[C:18]([CH:36]=1)[C:19]([NH:21][CH2:22][CH2:23][C:24]1[CH:29]=[CH:28][C:27]([CH2:30][C:31]([O:33]CC)=[O:32])=[CH:26][CH:25]=1)=[O:20].ClC1C=NC(OC)=C(C=1)C(NCCC1C=CC(CC(O)=O)=CC=1)=O>>[CH3:38][O:37][C:17]1[N:16]=[CH:15][CH:14]=[CH:36][C:18]=1[C:19]([NH:21][CH2:22][CH2:23][C:24]1[CH:29]=[CH:28][C:27]([CH2:30][C:31]([OH:33])=[O:32])=[CH:26][CH:25]=1)=[O:20]

Participants

4

Reactant 3

HCID 98369735-Chloro-2-methoxynicotinic acidHCID 20336029Ethyl 4-[2-(5-chloro-2-methoxynicotinoylamino)-ethyl]-phenylacetateHCID 23453042HCID 23453042, compound

Product 1

HCID 23453078HCID 23453078, compound

Procedure

with 5-chloro-2-methoxynicotinic acid, via ethyl 4-[2-(5-chloro-2-methoxynicotinoylamino)-ethyl]-phenylacetate (oil), 4-[2-(5-chloro-2-methoxynicotinoylamino)-ethyl]-phenylacetic acid; m.p. 157°-158° C., after recrystallization from ethanol.

Workup

  1. customm.p. 157°-158° C., after recrystallization from ethanol

Sources & evidence

ORD record
ord-89b0e8c35c4e427fa31d32fb2eda58c3
Source dataset
uspto-grants-1980_06
Patent number
US04207341

Reaction notes

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