Hydrochloric Acid → HCID 70515258, compound

Participants

Reaction Steps

The ethyl 2-[4-(2-aminoethyl)-phenyl]-2-methylpropionate hydrochloride (m.p. 150°-154° C.) used as starting material is obtained by the reaction of 2-(4-chloromethylphenyl)-2-methylpropionic acid (m.p. 121°-122° C.) with sodium cyanide. The 2-(4-cyanomethylphenyl)-2-methylpropionic acid obtained melts at 105°-106° C. This propionic acid derivative is catalytically hydrogenated in ethanolic hydrochloric acid solution to give 2-[4-(2-aminoethyl)-phenyl]-2-methylpropionic acid hydrochloride which, after recrystallization from isopropanol, melts at 247°-248° C. By esterification thereof with ethanol in hydrochloric acid solution, there is obtained the desired ethyl 2-[4-(2-aminoethyl)-phenyl]-2-methylpropionate hydrochloride.

Provenance & Evidence