HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane → 5-Chloro-2-methoxybenzoyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 5-Chloro-N-{2-[4-(2-hydroxyethyl)phenyl]ethyl}-2-methoxybenzamide | HCID 23453115 | — |
| Product | 5-Chloro-2-methoxybenzoyl chloride | HCID 12384176 | — |
| Product | 4-(2-Hydroxyethyl)-phenethylamine | HCID 21831841 | — |
Reaction Steps
The 2-{4-[2-(5-chloro-2-methoxybenzamido)-ethyl]-phenyl}-ethanol (oil) used as starting material is obtained by the acylation of 2-[4-(2-aminoethyl)-phenyl]-ethanol (oil) with 5-chloro-2-methoxybenzoyl chloride in anhydrous methylene chloride in the presence of triethylamine as acid acceptor.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04207341 |
| Source dataset | uspto-grants-1980_06 |
| ORD ID | ord-59164c5477194e0b9420b1506022f10b |
| Source note | uspto-grants-1980_06 |