5-Chloro-2-(2-methoxyethoxy)-benzoyl chloride → Ethyl 2-{4-[2-(5-chloro-2-(2-methoxyethoxy)-benzamido)-ethyl]-phenyl}-propionate

Participants

Reaction Steps

In a manner analogous to that described in Example 11, by the reaction of ethyl 2-[4-(2-aminoethyl)-phenyl]-propionate hydrochloride with 5-chloro-2-(2-methoxyethoxy)-benzoyl chloride (m.p. 49°-51° C.), there is obtained, via ethyl 2-{4-[2-(5-chloro-2-(2-methoxyethoxy)-benzamido)-ethyl]-phenyl}-propionate (oil), 2-{4-[2-(5-chloro-2-(2-methoxyethoxy)-benzamido)-ethyl]-phenyl}-propionic acid; m.p. 94°-96° C., after recrystallization from isopropanol/water.

Provenance & Evidence