Sodium Hydroxide → HCID 54572674, compound

Participants

Reaction Steps

1-(α-Methoxycarbonyl-4-methoxybenzyl)-3-[2-[4-{3-methoxycarbonyl-3-(2,2,2-trifluoroacetamido)propoxy}phenyl]-2-methoxyiminoacetamido]-2-azetidinone (0.19 g.) was dissolved in acetone (2 ml.). 1 N-Sodium hydroxide aqueous solution (0.9 ml.) was added to the solution at ambient temperature, and the mixture was stirred for 5 minutes. The acetone was distilled off from the reaction mixture, and the remaining solution was adjusted to pH 3 with 10% hydrochloric acid. The separated oil material was isolated by decantation, washed with acetone and water, and then pulverized with acetonitrile to give 1-(α-carboxy-4-methoxybenzyl)-3-[2-{4-(3-amino-3-carboxypropoxy)phenyl}-2-methoxyiminoacetamido]-2-azetidinone (0.02 g.). Mp 170° to 176° C. (dec.).

Provenance & Evidence