Methanol → HCID 54411637, compound

Participants

Reaction Steps

3-Phthalimido-1-(α-carboxybenzyl)-2-azetidinone (350 mg.) and N,N-dimethyl-1,3-propanediamine (310 mg.) were added to methanol (6 ml.), and the mixture was stirred at ambient temperature for 18 hours. Water (6 ml.) was poured into the reaction mixture under ice-cooling and then the mixture was adjusted to pH 5.8 to 6.0 with cation-exchange resin IRC-50 (Trade Mark, maker: Rohm & Haas Co.,) (20 ml.). The resin was removed by filtration and the filtrate was evaporated to dryness under reduced pressure. Acetonitrile was added to the residue (190 mg.) obtained and then the mixture was stirred under ice-cooling for 2.5 hours. The powder was collected by filtration to give 3-amino-1-(α-carboxybenzyl)-2-azetidinone (120 mg.).

Provenance & Evidence