HCID 54255546, compound → HCID 54381947, compound

Participants

Reaction Steps

3-(2-Phenylacetamido)-1-(α-methoxycarbonyl-4-benzyloxybenzyl)-2-azetidinone (70 mg) was dissolved in absolute ethanol (10 ml), and to the solution, there was added 10% palladium on carbon (30 mg). The mixture was subjected to catalytic reduction in a stream of hydrogen gas at ordinary temperature and ordinary atmospheric pressure. After a calculated volume of the hydrogen gas was absorbed into the mixture in the course of 3 hours, the catalyst was removed by filtration to give a filtrate, which was evaporated to dryness under reduced pressure. The resultant residue was treated with diethyl ether to give 3-(2-phenylacetamido)-1-(α-methoxycarbonyl-4-hydroxybenzyl)-2-azetidinone (40 mg), mp 171.5° to 175° C.

Provenance & Evidence