tert-Butanol → HCID 15592328, compound

Participants

Reaction Steps

A mixture of 1-(1-carboxy-2-methylpropyl)-3-(2-phenylacetamido)-2-azetidinone (1.50 g), triethylamine (0.51 g), diphenylphosphoryl azide (1.4 g) and tert-butyl alcohol (30 ml) was heated gradually, and refluxed under heating for 5 hours. After the reaction, the tert-butyl alcohol was removed by distillation from the reaction mixture under reduced pressure to give a residue, which was subjected to column chromatography on silica gel. Elution was carried out with a mixture of benzene and ethyl acetate, and the fractions containing a desired compound were collected. The eluate was evaporated to dryness under reduced pressure to give 1-(1-tert-butoxycarbonylamino-2-methylpropyl)-3-(2-phenylacetamido)-2-azetidinone (1.1 g), mp 64° to 66° C.

Provenance & Evidence