Benzene → HCID 86737050, compound

Participants

Reaction Steps

To a mixture of 3-[4-{3-tert-butoxycarbonylamino-3-(4-methoxybenzyloxycarbonyl)propoxy}phenylglyoxyloylamino]-1-(α-carboxybenzyl)-2-azetidinone (870 mg), benzene (4 ml) and anisol (1 ml), there was added 2,2,2-trifluoroacetic acid (2 ml) under ice-cooling. The mixture was stirred at the same temperature for 1.5 hours and then diethyl ether (50 ml) was added thereto. The mixture was stirred for half an hour and insoluble materials were collected by filtration and suspended in ethyl acetate (30 ml). After the suspension was stirred at ambient temperature for half an hour, insoluble materials were collected by filtration and then treated with diethyl ether to give 3-[4-(3-amino-3-carboxypropoxy)phenylglyoxyloylamino]-1-(α-carboxybenzyl)-2-azetidinone (0.52 g).

Provenance & Evidence