HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 70589991, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Isoamyl Alcohol | HCID 31260 | — |
| Reactant | (RS)-Naproxen methyl ester | HCID 529084 | — |
| Reactant | Sodium | HCID 5360545 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | HCID 70589991 | HCID 70589991 | — |
Reaction Steps
A mixture of 24.4 g. of methyl 6-methoxy-2-naphthyl-α-methylacetate, 25 g. of sodium metal, and 500 ml. of anhydrous iso-amyl alcohol are refluxed for 18 hours. The cooled reaction mixture is acidified by the addition of aqueous 1 N hydrochloric acid. The product is isolated by diethyl ether extraction to give methyl 6-methoxy-3,4-dihydro-2-naphthyl-α-methylacetate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04207241 |
| Source dataset | uspto-grants-1980_06 |
| ORD ID | ord-27799a8757aa40e09bbd305681c520ef |
| Source note | uspto-grants-1980_06 |