反应详情

2.7 parts of methylaminoacetonitrile hydrochloride was added to a solution of 2 parts of sodium hydroxide in 25 parts of water at ~15°. When the addition was complete a solution of 5.8 parts of 2-phenoxybenzoyl chloride in 50 parts of methylene chloride was added dropwise. The mixture was stirred vigorously for 5 hrs. at ~20°. The methylene chloride layer was then separated, washed with water and dried over magnesium sulfate. Removal of the magnesium sulfate by filtration and concentration of the filtrate gave 4.6 parts of N-cyanomethyl-N-methyl-2-phenoxybenzamide as a viscous oil. NMR (CDCl3) 3δ(S,3H,CH3), 4.1δ,4.3δ (2S,2H,CH2), 7.05δ, (m,9H,Aromatic H).

1. additionWhen the addition
2. additionwas added dropwise
3. customat ~20°
4. customThe methylene chloride layer was then separated
5. washwashed with water
6. dry with materialdried over magnesium sulfate
7. customRemoval of the magnesium sulfate
8. filtrationby filtration and concentration of the filtrate