HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Acetylbutyric acid → 1-(3'-Amino-4',6'-dimethylphenyl)-6-methyl-piperidin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Acetylbutyric acid | HCID 18407 | — |
| Reactant | 4,6-Diamino-1,3-m-xylene | HCID 854386 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 1-(3'-Amino-4',6'-dimethylphenyl)-6-methyl-piperidin-2-one | HCID 20494961 | — |
Reaction Steps
A solution of 65 g (0.5 mol) of 5-oxo-caproic acid and 70 g (0.51 mol) of 3-amino-4,6-dimethylaniline in 300 ml of methanol is hydrogenated at 130°-140° in the presence of Raney nickel. Yield: 110 g.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04208202 |
| Source dataset | uspto-grants-1980_06 |
| ORD ID | ord-df65ea40835d42188f9f9137dcd712c8 |
| Source note | uspto-grants-1980_06 |