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Levulinic Acid → 1-(3'-Amino-4',6'-dimethylphenyl)-5-methyl-pyrrolidin-2-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Levulinic Acid | HCID 11579 | — |
| 反応物 | 4,6-Diamino-1,3-m-xylene | HCID 854386 | — |
| 反応物 | HCID 178418361 | HCID 178418361 | — |
| 触媒 | Platinum oxide (PtO) | HCID 82844 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 1-(3'-Amino-4',6'-dimethylphenyl)-5-methyl-pyrrolidin-2-one | HCID 12833274 | 80% |
反応手順
A suspension of 0.2 g of platinum oxide in 25 ml of ethanol is treated with hydrogen and a solution of 34.8 g (0.3 mol) of levulinic acid and 85 g (0.62 mol) of 3-amino-4,6-dimethylaniline in 300 ml of ethanol is then added. The hydrogenation is carried out at room temperature. The desired pyrrolidinone derivative is obtained in a yield of about 80%.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04208202 |
| 出典データセット | uspto-grants-1980_06 |
| ORD ID | ord-f747abcd37754d728da8effe14acd0fa |
| 出典メモ | uspto-grants-1980_06 |