HCID 12833276, compound → 2,4-Dimethyl-5-(1-piperidinyl)benzenamine

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Reaction Steps

6.2 g of lithium aluminium hydride are introduced into 200 ml of absolute tetrahydrofurane. 26 g (0.12 mol) of 1-(3'-amino-4',6'-dimethylphenyl)-piperidin-2-one are added in portions, with stirring. The mixture is then refluxed for 1 hour. Excess LiAlH4 is destroyed with ethyl acetate. 2 N HCl is added to the mixture until the pH is 4-5, ether is added and the mixture is extraced twice with 2 N KOH solution. The organic phase is washed with water and saturated NaCl solution, dried with MgSO4, clarified with active charcoal and evaporated. The residue is distilled in a bulb tube. This gives 18.2 g (73%) of a yellow oil (boiling point 140°/0.001 mm Hg).

Provenance & Evidence