Desmethylmedazepam → HCID 20333780, compound

Participants

Reaction Steps

10 parts of 7-chloro-2,3-dihydro-5-phenyl-1H-1,4-benzodiazepine is dissolved in 75 parts by volume of methylene chloride. To this solution is added 6 parts of 2-chloroethylisocyanate and the resultant mixture left standing at ambient temperature for about 48 hours. Then, additional 2 parts of 2-chloroethylisocyanate is added to the mixture, the mixture heated on a steam bath for about 4 hours and the solvent removed to give a solid. The solid is washed with ether and crystallized from a mixture of methylene chloride and hexane to give 7-chloro-N-(2-chloroethyl)-2,3-dihydro-5-phenyl-1H-1,4-benzodiazepine-1-carboxamide, as yellow crystals melting at about 160°-161° C. This compound is represented by the following formula ##STR17##

Provenance & Evidence