Ethylene Glycol → 2-Methyl-4-((1-(trifluoromethyl)cyclopropyl)methyl)-1-trityl-1H-imidazole

HRID 170664Notes

Reaction equation

HRID 170664 reaction equation
[CH3:4][c:5]1[n:6]([C:19]([c:20]2[cH:21][cH:22][cH:23][cH:24][cH:25]2)([c:26]2[cH:27][cH:28][cH:29][cH:30][cH:31]2)[c:32]2[cH:33][cH:34][cH:35][cH:36][cH:37]2)[cH:7][c:8]([C:10](=[O:11])[C:12]2([C:15]([F:16])([F:17])[F:18])[CH2:13][CH2:14]2)[n:9]1.[K+:39].[NH2:2][NH2:3].[OH-:38].[OH2:1].[OH2:40].[OH:41][CH2:42][CH2:43][OH:44]>>[CH3:4][c:5]1[n:6]([C:19]([c:20]2[cH:21][cH:22][cH:23][cH:24][cH:25]2)([c:26]2[cH:27][cH:28][cH:29][cH:30][cH:31]2)[c:32]2[cH:33][cH:34][cH:35][cH:36][cH:37]2)[cH:7][c:8]([CH2:10][C:12]2([C:15]([F:16])([F:17])[F:18])[CH2:13][CH2:14]2)[n:9]1

Participants

7

Reactant 6

HCID 174Ethylene GlycolHCID 813Potassium CationHCID 961HydroxideHCID 962Water2×HCID 9321HydrazineHCID 68667421(2-Methyl-1-trityl-1H-imidazol-4-YL)(1-(trifluoromethyl)cyclopropyl)methanone

Product 1

HCID 591620382-Methyl-4-((1-(trifluoromethyl)cyclopropyl)methyl)-1-trityl-1H-imidazole

Sources & evidence

ORD record
ord-8d302484a57c40969986815e63ef24aa
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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