3'-Hydroxyphenylacetic acid → HCID 20333806, compound

HRID 1706652Notes

Reaction equation

HRID 1706652 reaction equation
[OH:1][C:2]1[CH:3]=[C:4]([CH2:8][C:9]([OH:11])=[O:10])[CH:5]=[CH:6][CH:7]=1.Br[CH2:13][C:14]1[CH:15]=[CH:16][C:17]2[O:21][C:20]([N+:22]([O-:24])=[O:23])=[C:19]([C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=3)[C:18]=2[CH:31]=1>>[N+:22]([C:20]1[O:21][C:17]2[CH:16]=[CH:15][C:14]([CH2:13][O:1][C:2]3[CH:3]=[C:4]([CH2:8][C:9]([OH:11])=[O:10])[CH:5]=[CH:6][CH:7]=3)=[CH:31][C:18]=2[C:19]=1[C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)([O-:24])=[O:23]

Participants

3

Reactant 2

HCID 121223'-Hydroxyphenylacetic acidHCID 13531604HCID 13531604, compound

Product 1

HCID 20333806HCID 20333806, compound

Procedure

Using the method of Example 10 and starting with 3-hydroxyphenylacetic acid and 5-bromomethyl-2-nitro-3-phenylbenzofuran the product obtained is recrystallized from ethanol to provide 3-[(2-nitro-3-phenylbenzofuran-5-yl)methoxy]phenylacetic acid, m.p. 144°-145° C.

Workup

  1. customobtained
  2. customis recrystallized from ethanol

Sources & evidence

ORD record
ord-d88e2eb25f174542a423038e03c5bf69
Source dataset
uspto-grants-1980_06
Patent number
US04208335

Reaction notes

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