HCID 57178653, compound → 4,5,6,7-Tetrahydro-N-methyl-4-benzothiazolamine

HRID 1706688Notes

Reaction equation

HRID 1706688 reaction equation
[CH3:1][N:2]=[C:3]1[C:8]2[N:9]=[CH:10][S:11][C:7]=2[CH2:6][CH2:5][CH2:4]1.[H][H]>C(O)C.[Pt]=O>[CH3:1][NH:2][CH:3]1[C:8]2[N:9]=[CH:10][S:11][C:7]=2[CH2:6][CH2:5][CH2:4]1

Participants

5

Reactant 2

HCID 57178653HCID 57178653, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 545021764,5,6,7-Tetrahydro-N-methyl-4-benzothiazolamineYield 80%

Reagents, catalysts & solvents 2

HCID 82844Platinum oxide (PtO)CatalystHCID 702EthanolSolvent

Procedure

Catalytic hydrogenation of the 4-methylimino derivative obtained in step (e) in ethanol containing excess methylamine, in the presence of platinum oxide, proceeds slowly at 50° C. under ordinary pressure. After the theoretical amount of hydrogen has been taken up, the solution is filtered, evaporated, and the residue is distilled: B.p.0.4 =86°-88° C.; Yield; 80%.

Workup

  1. customslowly at 50° C.
  2. filtrationthe solution is filtered
  3. customevaporated
  4. distillationthe residue is distilled
  5. customB.p.0.4 =86°-88° C.

Sources & evidence

ORD record
ord-803c985a363042a7a7bf760c26591dde
Source dataset
uspto-grants-1980_06
Patent number
US04208420

Reaction notes

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