反应详情

To a stirred mixture of 4.4 parts of 1-(1-methylethyl)-N-phenyl-4-piperidinamine, 5.3 parts of sodium carbonate and 180 parts of benzene are added dropwise 5 parts of benzeneacetyl chloride. Upon completion, stirring is continued overnight at reflux. The reaction mixture is cooled, washed successively with water, a sodium hydrogen carbonate solution and again with water, dried, filtered and evaporated. The residue is converted into the hydrochloride salt in 2,2'-oxybispropane and 2-propanol. The formed salt is filtered off and crystallized from a mixture of 2-propanol and 2,2'-oxybispropane, yielding 2,5 parts of N-[1-(1-methylethyl)-4-piperidinyl]N-phenylbenzeneacetamide hydrochloride; mp. 184.4° C.

1. temperatureat reflux
2. temperatureThe reaction mixture is cooled
3. washwashed successively with water
4. dry with materiala sodium hydrogen carbonate solution and again with water, dried
5. filtrationfiltered
6. customevaporated
7. filtrationThe formed salt is filtered off
8. customcrystallized from a mixture of 2-propanol and 2,2'-oxybispropane