Acetic Anhydride → HCID 70583977, compound

Participants

Reaction Steps

Methyl 6-azido-2,3,6-trideoxy-α-D-erythro-hexopyranoside (3.0 g, 16 mmol) in methanol (100 ml) containing acetic anhydride (2 ml) was hydrogenated over 10% palladium-on-charcoal (0.4 g) at room temperature under a pressure of 2.5 atms. for 5 h. The catalyst was filtered off and the filtrate was evaporated to dryness giving a syrupy residue which crystallized upon treatement with ether to yield 3.18 g, 98%. The product was recrystallized from chloroform-ether to give pure methyl 6-acetamido-2,3,6-trideoxy-α-D-erythro-hexopyranoside. M.p.: 117°-118°. [α]546121 -13° (c 1, chloroform).

Provenance & Evidence