Ethylene Glycol → HCID 86737061, compound

Participants

Reaction Steps

A mixture of 500 mg of 9,15-dioxo-13-prostenoic acid ethyl ester, 15 ml of dry benzene, 1 ml of ethyleneglycol and 5 mg of p-toluenesulphonic acid monohydrate is boiled for 16 hours on a water separator. After cooling, the mixture is diluted with 100 ml of diethyl and washed with aqueous NaHCO3 solution and water. The organic phase is dried over Na2SO4 and the solvent is distilled. After chromatographic purification of the residue (silica gel/diisopropyl ether), 9,9;15,15-bis-(ethylenedioxy)-13-prostenoic acid ethyl ester is obtained.

Provenance & Evidence