HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 20333072, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 1-(2-Hydroxyethyl)piperazine | HCID 7677 | — |
| Reactant | 6-Bromo-N-(6-methoxy-4-methyl-8-quinolinyl)hexanamide | HCID 612023 | — |
| Solvent | Benzene | HCID 241 | — |
| Product | HCID 20333072 | HCID 20333072 | 72.4% |
Reaction Steps
A mixture of 7 g (0.019 mol) of 6-bromo-N-(6-methoxy-4-methyl-8-quinolinyl)hexanamide and 4.4 g (0.038 mol) of hydroxyethylpiperazine in 100 ml of benzene was heated under reflux for 48 hours, allowed to cool, mixed well with 50 ml of water and filtered to collect the crude product. Recrystallization from toluene with hexane afforded 5.7 g (72%) of crystalline material, mp 88°-90°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04209519 |
| Source dataset | uspto-grants-1980_06 |
| ORD ID | ord-80e133a038b24f888f0381817f026baf |
| Source note | uspto-grants-1980_06 |