Formaldehyde → HCID 20333086, compound

Participants

Reaction Steps

A solution of formaldehyde (1.6 cm3, 40% aqueous solution) was added to a stirred solution of 4-benzoylureidopiperidine (5 g, 0.02 mol) and 2-methylindole (2.6 g, 0.02 mol) in acetic acid (12 cm3). The solution was allowed to stand for 5 hours and diluted with water (100 cm3). The precipitated solid was removed by filtration and discarded. The filtrate was basified by addition of ammonia to precipitate the product which was collected by filtration. The product was triturated with ethanol, then recrystallised from a mixture of acetonitrile (120 cm3) and water (12 cm3) to give the title compound as the pure base (1.65 g, 21%) m.p. 209°-11° C.

Provenance & Evidence