Ammonia → HCID 20333084, compound

Participants

Reaction Steps

A solution of formaldehyde (0.4 cm3, 40% aqueous solution) was added to a stirred solution of 1-(3methoxy benzoyl)-3-(piperid-4-yl)urea (1.39 g, 5 mmol) and indole (0.6 g, 5 mmol) in acetic acid (3 cm3). The solution was allowed to stand for 5 hours then diluted with water (50 cm3), basified by addition of ammonia and the precipitated product collected, washed with water, and dried yielding the title compound as the free base (2.1 g). The base was dissolved in hot ethanol (30 cm3), cooled, and acidified with ethanolic hydrogen chloride to precipitate the hydrochloride (2.3 g, 100%). Recrystallisation from aqueous methanol (60% methanol, 70 cm3) gave 1.8 g (81%) m.p. 234°-5° C.

Provenance & Evidence