Sodium → HCID 178513801, compound

Participants

Reaction Steps

To 300 ml of anhydrous methanol was added 0.92 g of sodium and then 4.26 g of ethyl 4-carbamoyl-5-hydroxy-1H-imidazole-2-acetate was added thereto under ice-cooling. 5 minutes thereafter, the mixture was warmed to a room temperature and stirred for 15 minutes. The resulting mixture was concentrated under vacuum and the residue was dissolved into 100 ml of water. After addition of 120 ml of 1 N aqueous hydrochloric acid, the precipitated crystals were collected, washed with ethanol and diisopropyl ether, and dried to give 3.04 g of 4-carbamoyl-5-hydroxy-1H-imidazole-2-acetic acid, m.p. 299° C. (decomposition). Yield: 82.2%.

Provenance & Evidence