Sodium Hydroxide → HCID 20333143, compound

Participants

Reaction Steps

A mixture of 1.55 g. (0.005 mole) of 3-benzyl-2-oxo-1-benzimidazolineacetic acid and 10 ml. of thionyl chloride dissolved in 300 ml. of chloroform is refluxed for a period of approximately 2.5-4 hours. After cooling to room temperature (~25° C.), the reaction mixture is slowly poured into a solution consisting of 4.5 g. of sodium hydroxide dissolved in 100 ml. of ammonium hydroxide. The resulting chloroform layer is then separated and subsequently evaporated to near dryness while under reduced pressure to give a residual solid. Recrystallization of the latter material from ethanol-water then yields pure 3-benzyl-2-oxo-1-benzimidazolineacetamide in fine crystalline form.

Provenance & Evidence