Tetrafluoro-m-phenylenediamine dihydrochloride → HCID 20333067, compound

HRID 1706986Notes

Reaction equation

Cl.F[C:3]1C=CC=CC=1C1C2C=C(Cl)C=CC=2N2N=C(C(N3CCN(C)CC3)=O)N=C2CN=1.[F:33][C:34]1[CH:66]=[CH:65][CH:64]=[CH:63][C:35]=1[C:36]([C:38]1[CH:43]=[C:42]([Cl:44])[CH:41]=[CH:40][C:39]=1[N:45]1[C:49]([CH2:50][N:51]([CH3:53])[CH3:52])=[N:48][C:47]([C:54]([N:56]2CCN(C)[CH2:58][CH2:57]2)=[O:55])=[N:46]1)=[O:37].C1(N)C(F)=C(F)C(F)=C(N)C=1F.Cl.Cl>>[CH:57]([NH:56][C:54]([C:47]1[N:48]=[C:49]([CH2:50][N:51]([CH3:52])[CH3:53])[N:45]([C:39]2[CH:40]=[CH:41][C:42]([Cl:44])=[CH:43][C:38]=2[C:36](=[O:37])[C:35]2[CH:63]=[CH:64][CH:65]=[CH:66][C:34]=2[F:33])[N:46]=1)=[O:55])([CH3:58])[CH3:3]

Participants

Reactant 3

HCID 149026Tetrafluoro-m-phenylenediamine dihydrochloride

HCID 20333015HCID 20333015, compound

HCID 20333063HCID 20333063, compound

Product 1

HCID 20333067HCID 20333067, compound

Procedure

from the base liberated from 23.8 g (0.050 mole) of 1-[[6-(o-fluorophenyl)-8-chloro-4H-s-triazolo[1,5-a][1,4]benzodiazepin-2-yl]-carbonyl]-4-methylpiperazine hydrochloride: -1-[[1-[2-(o-fluorobenzoyl)-4-chlorophenyl]-5-[(dimethylamino)-methyl]-1H-1,2,4-triazol-3-yl]-carbonyl]-4-methylpiperazine and the dihydrochloride thereof.

Sources & evidence

ORD record: ord-eaef04ef7d254ffc835a0e8e81972f0f
Source dataset: uspto-grants-1980_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04209516

Reaction notes

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