HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → Ethyl 2-(3,4-dichloroanilino)acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | N-(3,4-dichlorophenyl)glycine | HCID 351250 | — |
| Solvent | 1,1-Dichloroethane | HCID 6365 | — |
| Product | Ethyl 2-(3,4-dichloroanilino)acetate | HCID 2727804 | 78% |
Reaction Steps
A solution of 27.5 g (0.125 mol) of 3,4-dichloroanilinoacetic acid, 190 ml of dichloroethane, 15 ml (0.2 mol) of ethanol and 1.5 ml of concentrated H2SO4 is heated for 4 hours under reflux. It is washed with water and with dilute sodium bicarbonate, dried and evaporated to dryness in vacuo. The ester is recrystallised from ethanol and is obtained in a yield of 78%. It melts at 103°-104° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04209523 |
| Source dataset | uspto-grants-1980_06 |
| ORD ID | ord-dd68ddac0fc94193bf4c79fa646838c4 |
| Source note | uspto-grants-1980_06 |