Ethyl orthoformate → 6-Phenyl-1,2,4-triazolo[4,3-a]pyrimidine

HRID 1707045Notes

Reaction equation

HRID 1707045 reaction equation
[NH:1]([C:3]1[N:8]=[CH:7][C:6]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[CH:5][N:4]=1)[NH2:2].[CH:15](OCC)(OCC)OCC>>[C:9]1([C:6]2[CH:7]=[N:8][C:3]3[N:4]([CH:15]=[N:2][N:1]=3)[CH:5]=2)[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1

Participants

3

Reactant 2

HCID 31214Ethyl orthoformateHCID 141699362-Hydrazino-5-phenylpyrimidine

Product 1

HCID 203333416-Phenyl-1,2,4-triazolo[4,3-a]pyrimidine

Procedure

A mixture of 2.5 g. of 2-hydrazino-5-phenylpyrimidine and 25 ml. of triethyl orthoformate is heated for 16 hours under reflux. The material that separates is collected and crystallized from ethanol to give 1.5 g. of the product of the Example, m.p. 231° C.

Workup

  1. additionA mixture of 2.5 g
  2. temperatureunder reflux
  3. customThe material that separates is collected
  4. customcrystallized from ethanol
  5. customto give 1.5 g

Sources & evidence

ORD record
ord-9a4192171b444a14a381a1fef4bfd061
Source dataset
uspto-grants-1980_06
Patent number
US04209621

Reaction notes

Loading…