6-Phenyl-1,2,4-triazolo[4,3-a]pyrimidine → 6-(Phenyl)-1,2,4-triazolo[1,5-a]pyrimidine

HRID 1707047Notes

Reaction equation

HRID 1707047 reaction equation
[C:1]1([C:7]2[CH:8]=[N:9][C:10]3[N:11]([CH:13]=[N:14][N:15]=3)[CH:12]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1>C(O)=O>[C:1]1([C:7]2[CH:8]=[N:9][C:10]3[N:15]([N:14]=[CH:13][N:11]=3)[CH:12]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

3

Reactant 1

HCID 203333416-Phenyl-1,2,4-triazolo[4,3-a]pyrimidine

Product 1

HCID 100813826-(Phenyl)-1,2,4-triazolo[1,5-a]pyrimidine

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Procedure

A mixture of 1.0 g. of 6-(phenyl)-1,2,4-triazolo[4,3-a]pyrimidine and 10 ml. of 97% formic acid is refluxed for 5 hours and the excess formic acid is removed under reduced pressure. The solid residue is collected, washed with hexane and recrystallized from glacial acetic acid to give the product as crystals, m.p. 164°-167° C.

Workup

  1. additionA mixture of 1.0 g
  2. customthe excess formic acid is removed under reduced pressure
  3. customThe solid residue is collected
  4. washwashed with hexane
  5. customrecrystallized from glacial acetic acid

Sources & evidence

ORD record
ord-b6f8ba44ce114f2c87513d73709ee6a4
Source dataset
uspto-grants-1980_06
Patent number
US04209621

Reaction notes

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