Acetic Acid → 6-(Phenyl)-1,2,4-triazolo[1,5-a]pyrimidine

HRID 1707048Notes

Reaction equation

HRID 1707048 reaction equation
[C:1]1([C:7]([CH2:9]C=O)=N)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH2:12][C:13]1[N:17]=[CH:16][NH:15][N:14]=1.[C:18](O)(=O)C>>[C:1]1([C:7]2[CH:9]=[N:12][C:13]3[N:14]([N:15]=[CH:16][N:17]=3)[CH:18]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

4

Reactant 3

HCID 176Acetic AcidHCID 86737068(Phenyl)formimidoylacetaldehydeHCID 178418311HCID 178418311, compound

Product 1

HCID 100813826-(Phenyl)-1,2,4-triazolo[1,5-a]pyrimidine

Procedure

An equimolar mixture of (phenyl)formimidoylacetaldehyde and 3-amino-1,2,4-triazole in glacial acetic acid (5 ml. acetic acid to 0.01 mole of reagents) is refluxed for 2 hours and allowed to cool to room temperature. The solid which separates is collected, washed with glacial acetic acid and dried. The solid is recrystallized from glacial acetic acid to give the product, m.p. 164°-167° C.

Workup

  1. temperatureis refluxed for 2 hours
  2. customThe solid which separates is collected
  3. washwashed with glacial acetic acid
  4. customdried
  5. customThe solid is recrystallized from glacial acetic acid
  6. customto give the product, m.p. 164°-167° C.

Sources & evidence

ORD record
ord-283ad2879ae04803951bae3c9283c4f9
Source dataset
uspto-grants-1980_06
Patent number
US04209621

Reaction notes

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