HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Anhydride → 3-Hydroxy-3'-(trifluoromethyl)acrylophenone acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | 1,4-Dioxane | HCID 31275 | — |
| Reactant | 3-Hydroxy-3'-(trifluoromethyl)acrylophenone sodium salt | HCID 70590370 | — |
| Solvent | Water | HCID 962 | — |
| Product | 3-Hydroxy-3'-(trifluoromethyl)acrylophenone acetate | HCID 70477828 | — |
Reaction Steps
A suspension of 12.0 g. of 3-hydroxy-3'-(trifluoromethyl)acrylophenone sodium salt in 75 ml. of dioxane and 10 ml. of acetic anhydride is stirred at room temperature for 2 hours and then poured into water. The precipitate is collected by filtration, dissolved in methylene chloride and then passed through a hydrous magnesium silicate column and crystallized from methylene chloride-hexane to give the desired product, m.p. 55°-57° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04209621 |
| Source dataset | uspto-grants-1980_06 |
| ORD ID | ord-c32e3cc8f157486fa32b101490769740 |
| Source note | uspto-grants-1980_06 |