Ethyl orthopropionate → HCID 20333342, compound

HRID 1707078Notes

Reaction equation

[NH:1]([C:3]1[N:8]=[C:7]([C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([C:15]([F:18])([F:17])[F:16])[CH:10]=2)[CH:6]=[CH:5][N:4]=1)[NH2:2].[C:19](OCC)(OCC)(OCC)[CH2:20][CH3:21]>>[CH2:20]([C:21]1[N:4]2[CH:5]=[CH:6][C:7]([C:9]3[CH:14]=[CH:13][CH:12]=[C:11]([C:15]([F:18])([F:17])[F:16])[CH:10]=3)=[N:8][C:3]2=[N:1][N:2]=1)[CH3:19]

Participants

Reactant 2

HCID 66995Ethyl orthopropionate

HCID 20333332HCID 20333332, compound

Product 1

HCID 20333342HCID 20333342, compound

Procedure

A mixture of 1.50 g. of 2-hydrazino-4-(m-trifluoromethylphenyl)pyrimidine and 25 ml. of triethyl orthopropionate is refluxed for 8 hours. On cooling the desired compound is obtained by filtration, m.p. 223°-224° C.

Workup

additionA mixture of 1.50 g

Sources & evidence

ORD record: ord-64e76c7351d1471899e0ccc1e91d6181
Source dataset: uspto-grants-1980_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04209621

Reaction notes

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