Acetic Acid → 5-(2-Chlorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxylic acid

Participants

Reaction Steps

A mixture of 19.0 g. of 5-(2-chlorophenyl)-1,2-dihydro-2-oxo-3-pyridinecarbonitrile and 1:1 concentrated hydrochloric acid and glacial acetic acid is heated at reflux temperature for 16 hours. A yellow solid is separated which is collected by filtration and is washed with water to give 18.4 g. of the product of the Example as yellow needles, m.p. 299°-303° C.

Provenance & Evidence