Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | 1,3-Benzenediamine, N1,N1,N3,N3-tetramethyl- | HCID 89715 | — |
| Reactant | 3,4,5,6-Tetrachloro-2-carboxy-4'-diethylaminobenzophenone | HCID 19956611 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Fthalide | HCID 33791 | 103% |
Reaction Steps
A mixture of 2-(4-(diethylamino)benzoyl)-3,4,5,6-tetrachlorobenzoic acid (8.70 g.), N,N,N',N'-tetramethyl-m-phenylenediamine (3.61 g.) and acetic anhydride (5 ml.) was heated (to 90° C.). Addition of methanol (10 ml.) and slurrying the resulting product with methanol afforded 3-(2,4-bis(dimethylamino)phenyl)-3-(4-diethylamino)phenyl)-4,5,6,7-tetrachlorophthalide (I: X=(CH3)2N, Y2 =H, Y4 =(CH3CH2)2N, Z4 =Z5 =Z6 =Z7 =Cl) (5.60 g., m.p. 206°-207.5° C.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04209618 |
|---|
| Source dataset | uspto-grants-1980_06 |
|---|
| ORD ID | ord-d283eb55b2834c49ac3948d675786cd5 |
|---|
| Source note | uspto-grants-1980_06 |
|---|
