Uracil → Uridine 2',3',5'-tribenzoate

Participants

Reaction Steps

0.56 g. (5 mmol) of uracil, 2.52 g. (5 mmol) of 1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose were refluxed in 70 ml. of absolute acetonitrile with 1.41 g. (12 mmol) of NH4ClO4, 0.57 g. (3.5 mmol) of HMDS, and 1.68 g. (15.5 mmol) of TCS for 20 hours. The mixture was worked up as set forth in Example 1, thus producing 40% of crystalline uridine tribenzoate.

Provenance & Evidence