HuagongsheHuagongshe Chemistry Print Report · For research reference only
Uracil → 2',3',5'-Tri-O-benzoyluridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Uracil | HCID 1174 | — |
| Reactant | Hexamethyldisilazane | HCID 13838 | — |
| Reactant | beta-D-Ribofuranose, 1-acetate 2,3,5-tribenzoate | HCID 81455 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 2',3',5'-Tri-O-benzoyluridine | HCID 97046 | 43% |
Reaction Steps
0.56 g. (5 mmol) of uracil, 2.52 g. (5 mmol) of 1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose were refluxed in 70 ml. of absolute acetonitrile with 1.32 g. (12 mmol) of NaBF4, 0.57 g. (3.5 mmol) of HMDS, and 1.68 g. (15.5 mmol) of TCS for 2 hours. The mixture was worked up as set forth in Example 1, yielding 43% of crystalline uridine tribenzoate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04209613 |
| Source dataset | uspto-grants-1980_06 |
| ORD ID | ord-430ef20498d64a5f9cd44aa506a0428c |
| Source note | uspto-grants-1980_06 |