HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hexamethyldisilazane → HCID 22811363, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hexamethyldisilazane | HCID 13838 | — |
| Reactant | Perfluorobutanesulfonic acid | HCID 67815 | — |
| Reactant | beta-D-Ribofuranose, 1-acetate 2,3,5-tribenzoate | HCID 81455 | — |
| Reactant | Potassium | HCID 5462222 | — |
| Reactant | Piridin-4-one | HCID 17984897 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Solvent | Ethylacetate methanol | HCID 21584119 | — |
| Product | HCID 22811363 | HCID 22811363 | — |
Reaction Steps
0.47 g. (5 mmol) of 4-pyridone, 2.52 g. (5 mmol) of 1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose, and 4.06 g. (12 mmol) of the potassium salt of perfluorobutanesulfonic acid were refluxed with 0.29 g. (1.75 mmol) of HMDS and 1.49 g. (13.75 mmol) of TCS in 70 ml. of absolute acetonitrile for 12 hours. The usual working-up step (Example 1) yielded after chromatography on silica gel with ethyl acetate-methanol (95:5) 65% of amorphous 1-(2',3',5'-tri-O-benzoyl-β-D-ribofuranosyl)-4-pyridone.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04209613 |
| Source dataset | uspto-grants-1980_06 |
| ORD ID | ord-4f1ee4a2544749d498a446c5182f4419 |
| Source note | uspto-grants-1980_06 |