2-Chlorobenzyl chloride → HCID 178478036, compound

HRID 1707257Notes

Reaction equation

HRID 1707257 reaction equation
[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([C@H:10]3[CH2:15][CH2:14][C@H:13]([N:16]4[CH2:21][CH2:20][NH:19][CH2:18][CH2:17]4)[CH2:12][CH2:11]3)=[CH:9][C:4]=2[O:3][CH2:2]1.[Cl:22][C:23]1[CH:30]=[CH:29][CH:28]=[CH:27][C:24]=1[CH2:25]Cl>>[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([C@H:10]3[CH2:15][CH2:14][C@H:13]([N:16]4[CH2:21][CH2:20][N:19]([CH2:25][C:24]5[CH:27]=[CH:28][CH:29]=[CH:30][C:23]=5[Cl:22])[CH2:18][CH2:17]4)[CH2:12][CH2:11]3)=[CH:9][C:4]=2[O:3][CH2:2]1

Participants

3

Reactant 2

HCID 119062-Chlorobenzyl chlorideHCID 178420444HCID 178420444, compound

Product 1

HCID 178478036HCID 178478036, compound

Procedure

The title compound was prepared from trans 1-[4-(1,3-benzodioxol-5-yl)-1-cyclohexyl]piperazine and 2-chlorobenzyl chloride by the method described in example 15 to give the product (89%, mp: 89°-90° C.). Calc'd for C24H29ClN2O2 : C, 69.81%; H, 7.08%; N, 6.79%. Found: C, 69.50%; H, 7.03%; N, 6.71%.

Sources & evidence

ORD record
ord-11139a465f3d4024a664eff5f42823a9
Source dataset
uspto-grants-1994_10
Patent number
US05352678

Reaction notes

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