反应详情

45 g (0.14 mol) 1-bromo-8-(3-nitrophenyl-methylene)-7,9-decanedione and 28 g (0.28 mol) 2-amino-2-penten-4-one are boiled under reflux in 300 ml methanol for 24 h. The mixture is concentrated and the residue is prepurified by chromatography with toluene/acetone=99/1. The product thus obtained is chromatographed again over silica gel with toluene/ethyl acetate=8/2The title compound is obtained as a yellow oil. Yield: 10.3 g (16%).

1. concentrationThe mixture is concentrated
2. customThe product thus obtained
3. customis chromatographed again over silica gel with toluene/ethyl acetate=8/2The title compound
4. customis obtained as a yellow oil