Sodium Iodide → HCID 67820037, compound

Participants

Reaction Steps

10 g (21 mmol) 5-acetyl-3-(8-bromo-octanoyl)-1,4-dihydro-2,6-dimethyl-4(3-nitrophenyl)-pyridine are reacted first with 6.3 g (42 mmol) sodium iodide and then with 11. 5 g (40 mmol) 4,4-diphenylpiperidine hydrochloride, as described for starting compound B. Working up is carried out as described for starting compound B. The crude product is chromatographed with increasing polarity, first with toluene/acetone=9/1 and finally with toluene/acetone =6/4. The product thus obtained is recrystallized from 70 ml acetonitrile. The title compound is obtained as a yellow solid. Yield: 11 g (82%). M.p. 141°-145° C. (acetonitrile).

Provenance & Evidence