HRID1707283

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID5238

Sodium Iodide

INa

HCID3047504

Piperidine, 4,4-diphenyl-, hydrochloride

C17H20ClN

结构：CC(=O)C1=C(OCOCCCl)NC(C)=C(C(=O)OC(C)(C)C)C1c1cccc([N+](=O)[O-])c1

HCID18963000

未命名化合物

PRODUCTS

生成物

结构：CC(=O)C1=C(COCCN2CCC(c3ccccc3)(c3ccccc3)CC2)NC(C)=C(C(=O)OC(C)(C)C)C1c1cccc([N+](=O)[O-])c1.Cl

HCID67820118

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID3283

Diethyl Ether

C4H10O

PROCEDURE

实验过程

8.5 g (19 mmol) 3-acetyl-5-tert-butoxycarbonyl-2-(2-chloro-1-ethoxy)methoxy-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-pyridine are reacted first with 5.6 g (38 mmol) sodium iodide, as described for starting compound B, and then with 10.3 g (36 mmol) 4,4-diphenylpiperidine hydrochloride. Working up is carried out as described for starting compound B. The crude product is chromatographed with toluene/acetone=9/1. The product thus obtained is taken up in 50 ml diethyl ether. The title compound is precipitated by addition of ethereal hydrochloric acid. Yield: 11 g (84%). M.p. 175°-177° C. (diethyl ether).

WORKUP

后处理

customThe crude product is chromatographed with toluene/acetone=9/1
customThe product thus obtained
customThe title compound is precipitated by addition of ethereal hydrochloric acid

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-7238e8552bea4b748c7cd9666a72d11e
来源数据集: uspto-grants-1994_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05352684
来源说明: uspto-grants-1994_10

反应 SMILES

[C:1]([C:4]1[CH:9]([C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([N+:16]([O-:18])=[O:17])[CH:11]=2)[C:8]([C:19]([O:21][C:22]([CH3:25])([CH3:24])[CH3:23])=[O:20])=[C:7]([CH3:26])[NH:6][C:5]=1OCOCC[Cl:32])(=[O:3])[CH3:2].[I-].[Na+].Cl.[C:36]1([C:42]2([C:48]3[CH:53]=[CH:52][CH:51]=[CH:50][CH:49]=3)[CH2:47][CH2:46][NH:45][CH2:44][CH2:43]2)[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=1>C(OCC)C>[ClH:32].[C:1]([C:4]1[CH:9]([C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([N+:16]([O-:18])=[O:17])[CH:11]=2)[C:8]([C:19]([O:21][C:22]([CH3:25])([CH3:23])[CH3:24])=[O:20])=[C:7]([CH3:26])[NH:6][C:5]=1[CH2:22][O:21][CH2:19][CH2:8][N:45]1[CH2:44][CH2:43][C:42]([C:48]2[CH:53]=[CH:52][CH:51]=[CH:50][CH:49]=2)([C:36]2[CH:37]=[CH:38][CH:39]=[CH:40][CH:41]=2)[CH2:47][CH2:46]1)(=[O:3])[CH3:2]