HCID 67849505, compound → HCID 67849536, compound

HRID 1707291Notes

Reaction equation

HRID 1707291 reaction equation
C([O:3][C:4](=[O:40])[CH2:5][O:6][C:7]1[CH:12]=[C:11]([C:13](=[O:24])[C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([C:20]([O:22]C)=[O:21])[CH:15]=2)[CH:10]=[CH:9][C:8]=1[O:25][CH2:26][CH2:27][CH2:28][CH2:29]/[CH:30]=[CH:31]/[C:32]1[CH:37]=[CH:36][C:35]([O:38][CH3:39])=[CH:34][CH:33]=1)C>CO.[OH-].[Na+]>[C:20]([C:16]1[CH:15]=[C:14]([CH:19]=[CH:18][CH:17]=1)[C:13]([C:11]1[CH:10]=[CH:9][C:8]([O:25][CH2:26][CH2:27][CH2:28][CH2:29]/[CH:30]=[CH:31]/[C:32]2[CH:33]=[CH:34][C:35]([O:38][CH3:39])=[CH:36][CH:37]=2)=[C:7]([CH:12]=1)[O:6][CH2:5][C:4]([OH:40])=[O:3])=[O:24])([OH:22])=[O:21]

Participants

4

Reactant 1

HCID 67849505HCID 67849505, compound

Product 1

HCID 67849536HCID 67849536, compoundYield 79.4%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 14798Sodium HydroxideSolvent

Procedure

Under the conditions of example 1B, 30 mg of 5-(3-methoxycarbonylbenzoyl)-2-[6-(4-methoxyphenyl)-(5E)-5-hexenyloxy]-phenoxy acetic acid ethyl ester is saponified in 1 ml of methanol with 1 ml of In sodium hydroxide solution and worked up. 22 mg of 5-(3-carboxybenzoyl)-2-[6-(4-methoxyphenyl)-(5E)-5hexenyloxy]-phenoxy acetic acid is obtained as colorless oil.

Sources & evidence

ORD record
ord-2d10a9c801f9464297a26213e1254819
Source dataset
uspto-grants-1994_10
Patent number
US05352701

Reaction notes

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